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Bovine Thrombin
RMBIO thrombin from bovine plasma has a wide range of applications and is offered in various package sizes as a freeze-dried product, based on activity.
- As a coagulation protein, may be used for various clotting studies.
- Defibrination of human plasma, producing serum matrices to be used as controls and standards.
- Useful in polyclonal antibody production
- 60-200 US units/mg protein
- Bovine thrombin is provided as a lyophilized powder with specific NIH units/vial or at customers’ specification
- We fractionate the thrombin fraction using a highly effective series of extraction and chromatographic filtration steps to retain maximum product potency.
- Final solution is filtered aseptically through 0.2 µ filters before lyophilization
- Storage conditions: 2 – 8° C.
Bovine thrombin is an enzyme that activates factor XIII and converts fibrogen into fibrin. Therefore it's primary use is in the defibrination of plasma to produce serum matrixes to be used as controls and standards.
Bovine thrombin from RMBIO is produced as a lyophilized powder that is activated from highly purified prothrombin. Our final product is derived from bovine raw material through a proprietary fractionation process. There are several methods available to determine the specific activity of thrombin. RMBIO employs a method recommended by NIH and it is based on a visual observation of clotting times. NIH units are defined as the amount of enzyme which clots 1.0% fibrinogen solution or plasma with identical reactivity in 15 seconds at 37oC, pH 7.2 ± 0.1 at sodium chloride concentration of 0.15M (normal saline).
We use only the highest quality thrombin from bovine plasma that has been sourced from Australia/New Zealand or domestically. Bovine Thrombin can be customized for your every research need at our hi-tech and modern facility in Missoula, MT.
Safe Sourced and Enhanced Manufacturing Processes
Bovine Thrombin specific product test requirements and typical values are given below:
| Parameter | Method | Specification |
|---|---|---|
| pH (1% solution) | pH Meter | 6.5 - 7.5 |
| Thrombin Activity | Coagulation | 50,000 - 150,000 units/g powder |
| Specific Thrombin Activity | Clotting Assay | 90 - 250 US units/mg protein |
| Salts | Glycine, Sodium Chloride, Calcium Chloride | |
| Reconstitution | Normal Saline |
| Parameter | Method | Specification |
|---|---|---|
| pH (1% solution) | pH Meter | 6.5 - 7.5 |
| Thrombin Activity | Coagulation | 50,000 - 150,000 units/g powder |
| Specific Thrombin Activity | Clotting Assay | 90 - 250 US units/mg protein |
| Salts | Glycine, Sodium Chloride, Calcium Chloride | |
| Reconstitution | Normal Saline |
Documents
Certificate of Analysis
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