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Heat inactivated and gamma irradiated Donor Equine Serum in a 500 milliliter bottle and a 100 milliliter bottle.

Donor Horse Serum - Heat Inactivated and Gamma Irradiated Equine Serum

Donor horse serum from RMBIO is derived from US origin veterinary-inspected and controlled herds. Heat inactivation helps protect against growth inhibiting immune factors like serum complement that may be present in the serum. The serum is then gamma irradiated at an industry standard dose of 25-40kGy.
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Catalog Number : DES-BHG
Purified from validated raw materials of the United State
500 ML
50 ML
Special Order for bulk

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Product Details

Equine serum can be a cost-effective alternative to fetal bovine serum for use in a variety of cell culture applications. RMBIO obtains donor horse serum from closed herds that are carefully controlled and inspected by veterinarians. Horses are regularly tested for equine infectious anemia using Coggins tests. Before collection, donor horses are fasted to ensure lower lipid levels. All lots of equine serum are 0.2µm sterile filtered and feature low hemoglobin levels.

  • Gamma irradiated at 25-40kGy
  • Heat inactivated at 56°C for 30 minutes
  • Sterility, Endotoxin, and Mycoplasma tested
  • 9CFR tested
  • 0.2µm sterile filtered
  • Manufactured at our GMP compliant and FDA registered facility
  • Raw material is sourced from audited suppliers offering full traceability
  • Custom bottle sizes available upon request
  • Storage conditions: ≤ -10° C

Heat Inactivation 101
Heat inactivation is an industry standard treatment that helps protect against growth inhibiting immune factors like serum complement that may be present in the serum. Serum complement can have undesirable impacts on immunological endpoints like detection of neutralizing antibodies, or on the proliferation of viruses. RMBIO manufactures heat inactivated equine serum by raising the temperature of the serum to 56°C in a water bath and strictly maintaining the condition for 30 minutes.

Gamma Irradiation 101
Gamma irradiation is a physical inactivation approach used to achieve pathogen reduction in the serum. This mitigates risk from low-level contaminants that may not be detected through viral or mycoplasma testing. RMBIO serum is gamma irradiated via controlled exposure to Cobalt 60 at an industry standard dose of 25-40kGy. Most typical viral contaminants of equine serum are readily inactivated at this irradiation range. Advantages of gamma irradiation include:

  1. No potential for residual contaminants
  2. Widely accepted by pharmaceutical and research industries
  3. Accepted by regulatory agencies
  4. Minimal effect on product performance
  5. Effective virus inactivation

Donor Horse Serum - Equine Serum specific product test requirements and typical values are given below:

Parameter Method Specification
Osmolality Osmometer 206 - 345 mOsm/Kg
pH pH Meter 6.0 - 8.5
Total Protein Chemistry Analyzer 6.0 - 9.5 g/gL
Endotoxin LAL ≤ 50 EU/mL
Mycoplasma 9CFR 113.28 Not Detected
Sterility 9CFR 113.26 No Growth
Viral Analysis 9CFR 113.53 Not Detected
Gamma Irradiated 25-40 kGy
Product is heated at 56°C for 30 minutes to inactivate serum complement.

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