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IgG depleted and gamma irradiated US origin Fetal Bovine Serum in a transparent 500 milliliter bottle.

Fetal Bovine Serum (FBS) IgG Depleted and Gamma Irradiated

RMBIO’s IgG Depleted FBS is manufactured using a proprietary chromatography process to meet a stringent IgG specification of < 5 µg/mL while maintaining natural cellular viability and biological growth-promotion characteristics. We then apply an industry standard gamma irradiation dose of 25-40kGy.
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Catalog Number : FBS-BAG
Purified from validated raw materials of the United States
50 ML
Special Order for bulk

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Product Details

RMBIO uses premium grade FBS as the starting material for our IgG Depleted FBS. We then utilize a series of chromatography procedures to reduce the IgG content. The resulting FBS has an average IgG level of less than 5 µg/mL and cell growth performance comparable to the starting material. The average level of IgG in normal fetal calf serum is approximately 70-300 µg/mL.

  • Gamma irradiated at 25-40kGy
  • Total IgG content below 5 µg/mL
  • IgG depleted FBS performs well in monoclonal antibody production
  • Triple 0.1 µm filtered
  • Large lot sizes >1000 Liters available
  • Custom packaging sizes available upon request
  • All fetal bovine serum is fully traceable and is sourced from audited suppliers
  • Storage conditions: ≤ -10° C


Gamma Irradiation 101
Gamma irradiation is a physical inactivation approach used to achieve pathogen reduction in the serum. This mitigates risk from low-level contaminants that may not be detected through viral or mycoplasma testing. RMBIO serum is gamma irradiated via controlled exposure to Cobalt 60 at an industry standard dose of 25-40kGy. Most typical viral contaminants of bovine serum are readily inactivated at this irradiation range. Advantages of gamma irradiation include:

  • No potential for residual contaminants
  • Widely accepted by pharmaceutical and research industries
  • Accepted by regulatory agencies
  • Minimal effect on product performance
  • Effective virus inactivation

    IgG Depleted Fetal Bovine Serum (FBS) specific product test requirements and typical values are given below:

    Parameter Method Specification
    IgG ELISA < 5.0
    Total Protein Colorimetric Assay 3.0 - 4.5 g/dL
    Osmolality By Osmometer 280 - 340 mOsm/Kg
    pH pH Meter 7.0 - 8.0
    Hemoglobin Contract Lab < 25 mg/dl
    Albumin Contract Lab 1.7 - 3.4 g/dL
    Endotoxin LAL < 10 EU/ml
    Electrophoretic ID Gel Electrophoresis Characteristic
    Other Parameters Comprehensive Chemistry Testing As Reported
    Gamma Irradiated 25-40kGy

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