Acidic Fibroblast Growth Factor aFGF
Recombinant Human Acidic Fibroblast Growth Factor (aFGF), Fibroblast Growth Factor 1 (FGF-1), is a non-glycosylated 17-18 kDa protein consisting of a 155 amino acid polypeptide and a member of the fibroblast growth factor family of proteins. The function of aFGF is to promote cell proliferation, differentiation, and migration which is mediated by binding to the FGF receptor (FGFR) on the surface of cells, leading to the activation of intracellular signaling pathways that regulate various cellular processes.
aFGF is involved in various physiological and pathological processes, such as wound healing, angiogenesis, and cancer. In wound healing, aFGF stimulates the growth and migration of fibroblasts, which are essential for tissue repair. In angiogenesis, aFGF promotes the growth and differentiation of blood vessels, which is important for tissue development and repair.
In cancer, aFGF has been found to be overexpressed in various types of tumors, where it promotes cell proliferation, angiogenesis, and metastasis. As a result, aFGF has been identified as a potential target for cancer therapy.
In addition, aFGF has been used in medical treatments for various conditions, such as chronic wounds, ulcers, and ischemic heart disease. It has also been used in some cosmetic products for its potential skin-regenerating effects.
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