RMBIO produces high-quality, low hemoglobin, heat inactivated, US sourced calf serum for use in cell culture media. Bovine calf serum is often used as an alternative to Fetal Bovine Serum (FBS) as it’s available at a fraction of the price. Heat inactivation helps protect against growth inhibiting immune factors like serum complement that may be present in the serum.

• Heat inactivated at 56°C for 30 minutes
• Average endotoxin level*: < 2 EU/ml (specification = ≤ 10.0 EU/ml)
• Average hemoglobin level*: < 15 mg/dL (specification = < 30 mg/dL)
• Sterile 0.2 µm filtered
• 9CFR tested
• Manufactured at our GMP compliant and FDA registered facility
• Large volume lot sizes available
• Custom bottle sizes and containers available
• Storage conditions: ≤ -10° C

*Data based on last 10 lots produced.

Heat Inactivation 101
Heat inactivation is an industry standard treatment that helps protect against growth inhibiting immune factors like serum complement that may be present in the serum. Serum complement can have undesirable impacts on immunological endpoints like detection of neutralizing antibodies, or on the proliferation of viruses. RMBIO manufactures heat inactivated bovine calf serum by raising the temperature of the serum to 56°C in a water bath and strictly maintaining the condition for 30 minutes.